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| H (Match allé) | Monarcas Morelia | - | Club Tijuana | 3:1 (1:0) | ||
| R (match retour) | Club Tijuana | - | Monarcas Morelia | 3:1 (3:0) | ||
| H (Match allé): 27.11.2019 16:00 | R (match retour): 01.12.2019 06:00 | |||||
| H (Match allé) | CF América | - | Atlas Guadalajara | 2:1 (0:1) | ||
| R (match retour) | Atlas Guadalajara | - | CF América | 1:0 (1:0) | ||
| H (Match allé): 27.11.2019 17:00 | R (match retour): 30.11.2019 17:00 | vainqueur: Atlas Guadalajara | ||||
| H (Match allé) | Deportivo Guadalajara | - | CF Monterrey | 1:1 (1:0) | ||
| R (match retour) | CF Monterrey | - | Deportivo Guadalajara | 1:0 (0:0) | ||
| H (Match allé): 27.11.2019 19:00 | R (match retour): 30.11.2019 16:00 | vainqueur: CF Monterrey | ||||
| H (Match allé) | CD Veracruz | - | Santos Laguna | 1:1 (0:1) | ||
| R (match retour) | Santos Laguna | - | CD Veracruz | 2:1 (1:1) | ||
| H (Match allé): 28.11.2019 23:00 | R (match retour): 01.12.2019 18:00 | vainqueur: Santos Laguna | ||||
