 |
 |
|
|
| 16.09.2021 | 16:00 | Atlético San Luis | - | Club Tijuana | 3:0 (2:0) | |
| 17.09.2021 | 16:00 | Club Necaxa | - | Atlas Guadalajara | 1:2 (1:1) | |
| 18.09.2021 | 16:00 | Mazatlán FC | - | Pumas UNAM | 2:1 (2:1) | |
| 16:00 | Deportivo Toluca | - | CF América | 3:1 (1:1) | ||
| 16:00 | Club León | - | FC Juárez | 2:0 (1:0) | ||
| 16:00 | Deportivo Guadalajara | - | CF Pachuca | 1:2 (0:1) | ||
| 19.09.2021 | 16:00 | Cruz Azul | - | Gallos Blancos | 1:1 (0:1) | |
| 16:00 | CF Monterrey | - | UANL Tigres | 0:1 (0:1) | ||
| 18:00 | Santos Laguna | - | Puebla FC | 4:2 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 9 | 5 | 2 | 2 | 15:10 | 5 | 17 |
| 2 |
|
Club León | 9 | 5 | 2 | 2 | 11:8 | 3 | 17 |
| 3 |
|
CF América | 9 | 4 | 4 | 1 | 17:11 | 6 | 16 |
| 4 |
|
Santos Laguna | 9 | 4 | 3 | 2 | 16:13 | 3 | 15 |
| 5 |
|
Club Tijuana | 9 | 4 | 3 | 2 | 13:10 | 3 | 15 |
| 6 |
|
Club Necaxa | 9 | 4 | 2 | 3 | 15:12 | 3 | 14 |
| 7 |
|
Gallos Blancos | 9 | 4 | 2 | 3 | 12:10 | 2 | 14 |
| 8 |
|
CF Pachuca | 9 | 3 | 4 | 2 | 10:9 | 1 | 13 |
| 9 |
|
Atlas Guadalajara | 9 | 4 | 1 | 4 | 11:12 | -1 | 13 |
| 10 |
|
CF Monterrey | 9 | 3 | 2 | 4 | 15:12 | 3 | 11 |
| 11 |
|
Atlético San Luis | 9 | 3 | 2 | 4 | 18:16 | 2 | 11 |
| 12 |
|
UANL Tigres | 9 | 3 | 2 | 4 | 11:10 | 1 | 11 |
| 13 |
|
Cruz Azul | 9 | 2 | 5 | 2 | 7:7 | 0 | 11 |
| 14 |
|
Puebla FC | 9 | 3 | 2 | 4 | 16:20 | -4 | 11 |
| 15 |
|
Deportivo Guadalajara | 9 | 3 | 2 | 4 | 11:15 | -4 | 11 |
| 16 |
|
Mazatlán FC | 9 | 3 | 2 | 4 | 12:17 | -5 | 11 |
| 17 |
|
Pumas UNAM | 9 | 2 | 2 | 5 | 14:20 | -6 | 8 |
| 18 |
|
FC Juárez | 9 | 0 | 2 | 7 | 5:17 | -12 | 2 |
| Play-off |
