 |
 |
|
| 06.01.2022 | 16:00 | Atlético San Luis | - | CF Pachuca | 0:2 (0:2) | |
| 07.01.2022 | 16:00 | Puebla FC | - | CF América | 1:5 (1:3) | |
| 08.01.2022 | 16:00 | CF Monterrey | - | Gallos Blancos | 0:0 (0:0) | |
| 16:00 | Cruz Azul | - | Club Tijuana | 0:1 (0:0) | ||
| 09.01.2022 | 16:00 | Deportivo Guadalajara | - | Mazatlán FC | 1:0 (1:0) | |
| 16:00 | Pumas UNAM | - | Deportivo Toluca | 1:1 (0:0) | ||
| 12.01.2022 | 18:00 | Santos Laguna | - | UANL Tigres | 1:3 (0:0) | |
| 19.01.2022 | 16:00 | Club León | - | Atlas Guadalajara | 1:1 (1:1) | |
| 25.03.2022 | 16:00 | FC Juárez | - | Club Necaxa | 3:2 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 1 | 1 | 0 | 0 | 5:1 | 4 | 3 |
| 2 |
|
UANL Tigres | 1 | 1 | 0 | 0 | 3:1 | 2 | 3 |
| 3 |
|
CF Pachuca | 1 | 1 | 0 | 0 | 2:0 | 2 | 3 |
| 4 |
|
FC Juárez | 1 | 1 | 0 | 0 | 3:2 | 1 | 3 |
| 5 |
|
Club Tijuana | 1 | 1 | 0 | 0 | 1:0 | 1 | 3 |
|
Deportivo Guadalajara | 1 | 1 | 0 | 0 | 1:0 | 1 | 3 | |
| 7 |
|
Atlas Guadalajara | 1 | 0 | 1 | 0 | 1:1 | 0 | 1 |
|
Club León | 1 | 0 | 1 | 0 | 1:1 | 0 | 1 | |
|
Deportivo Toluca | 1 | 0 | 1 | 0 | 1:1 | 0 | 1 | |
|
Pumas UNAM | 1 | 0 | 1 | 0 | 1:1 | 0 | 1 | |
| 11 |
|
CF Monterrey | 1 | 0 | 1 | 0 | 0:0 | 0 | 1 |
|
Gallos Blancos | 1 | 0 | 1 | 0 | 0:0 | 0 | 1 | |
| 13 |
|
Club Necaxa | 1 | 0 | 0 | 1 | 2:3 | -1 | 0 |
| 14 |
|
Cruz Azul | 1 | 0 | 0 | 1 | 0:1 | -1 | 0 |
|
Mazatlán FC | 1 | 0 | 0 | 1 | 0:1 | -1 | 0 | |
| 16 |
|
Santos Laguna | 1 | 0 | 0 | 1 | 1:3 | -2 | 0 |
| 17 |
|
Atlético San Luis | 1 | 0 | 0 | 1 | 0:2 | -2 | 0 |
| 18 |
|
Puebla FC | 1 | 0 | 0 | 1 | 1:5 | -4 | 0 |
| Play-off |
