 |
 |
|
|
| 20.01.2022 | 16:00 | Atlético San Luis | - | FC Juárez | 7:1 (6:1) | |
| 21.01.2022 | 16:00 | Puebla FC | - | Club Tijuana | 0:2 (0:2) | |
| 17:00 | Mazatlán FC | - | Deportivo Toluca | 1:0 (0:0) | ||
| 22.01.2022 | 16:00 | Deportivo Guadalajara | - | Gallos Blancos | 0:0 (0:0) | |
| 16:00 | Club León | - | CF Pachuca | 4:3 (2:1) | ||
| 16:00 | CF Monterrey | - | Cruz Azul | 2:2 (0:1) | ||
| 23.01.2022 | 16:00 | Pumas UNAM | - | UANL Tigres | 2:1 (0:1) | |
| 18:00 | Santos Laguna | - | Club Necaxa | 0:3 (0:3) | ||
| 27.01.2022 | 16:00 | CF América | - | Atlas Guadalajara | 3:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club León | 3 | 2 | 1 | 0 | 7:5 | 2 | 7 |
| 2 |
|
Pumas UNAM | 3 | 2 | 1 | 0 | 4:2 | 2 | 7 |
| 3 |
|
Deportivo Guadalajara | 3 | 2 | 1 | 0 | 3:1 | 2 | 7 |
| 4 |
|
Atlético San Luis | 3 | 2 | 0 | 1 | 10:4 | 6 | 6 |
| 5 |
|
CF América | 3 | 2 | 0 | 1 | 9:4 | 5 | 6 |
| 6 |
|
UANL Tigres | 3 | 2 | 0 | 1 | 8:4 | 4 | 6 |
| 7 |
|
Club Tijuana | 3 | 2 | 0 | 1 | 4:2 | 2 | 6 |
| 8 |
|
Mazatlán FC | 3 | 2 | 0 | 1 | 3:2 | 1 | 6 |
| 9 |
|
Club Necaxa | 3 | 1 | 1 | 1 | 6:4 | 2 | 4 |
| 10 |
|
Deportivo Toluca | 3 | 1 | 1 | 1 | 5:4 | 1 | 4 |
| 11 |
|
FC Juárez | 3 | 1 | 1 | 1 | 4:9 | -5 | 4 |
| 12 |
|
CF Pachuca | 3 | 1 | 0 | 2 | 6:6 | 0 | 3 |
| 13 |
|
CF Monterrey | 3 | 0 | 3 | 0 | 3:3 | 0 | 3 |
| 14 |
|
Cruz Azul | 3 | 0 | 2 | 1 | 2:3 | -1 | 2 |
| 15 |
|
Gallos Blancos | 3 | 0 | 2 | 1 | 0:1 | -1 | 2 |
| 16 |
|
Atlas Guadalajara | 3 | 0 | 1 | 2 | 3:7 | -4 | 1 |
| 17 |
|
Santos Laguna | 3 | 0 | 0 | 3 | 3:10 | -7 | 0 |
| 18 |
|
Puebla FC | 3 | 0 | 0 | 3 | 2:11 | -9 | 0 |
| Play-off |
