 |
 |
|
|
| 11.02.2022 | 16:00 | Puebla FC | - | Atlas Guadalajara | 1:2 (1:2) | |
| 17:00 | Mazatlán FC | - | Club Tijuana | 0:2 (0:1) | ||
| 12.02.2022 | 16:00 | Atlético San Luis | - | Deportivo Toluca | 4:1 (3:0) | |
| 16:00 | Cruz Azul | - | Club Necaxa | 0:1 (0:1) | ||
| 16:00 | Deportivo Guadalajara | - | UANL Tigres | 0:1 (0:0) | ||
| 16:00 | CF Monterrey | - | FC Juárez | 1:0 (1:0) | ||
| 18:00 | Santos Laguna | - | CF América | 0:0 (0:0) | ||
| 13.02.2022 | 16:00 | Pumas UNAM | - | Club León | 2:1 (1:1) | |
| 14.02.2022 | 19:00 | CF Pachuca | - | Gallos Blancos | 2:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético San Luis | 5 | 4 | 0 | 1 | 15:5 | 10 | 12 |
| 2 |
|
UANL Tigres | 5 | 4 | 0 | 1 | 12:6 | 6 | 12 |
| 3 |
|
Pumas UNAM | 5 | 3 | 2 | 0 | 7:4 | 3 | 11 |
| 4 |
|
Club Tijuana | 5 | 3 | 1 | 1 | 7:3 | 4 | 10 |
| 5 |
|
Club León | 5 | 3 | 1 | 1 | 10:8 | 2 | 10 |
| 6 |
|
Deportivo Guadalajara | 5 | 3 | 1 | 1 | 5:3 | 2 | 10 |
| 7 |
|
CF Pachuca | 5 | 3 | 0 | 2 | 10:8 | 2 | 9 |
| 8 |
|
CF América | 5 | 2 | 1 | 2 | 9:5 | 4 | 7 |
| 9 |
|
Club Necaxa | 5 | 2 | 1 | 2 | 8:6 | 2 | 7 |
| 10 |
|
Deportivo Toluca | 5 | 2 | 1 | 2 | 9:8 | 1 | 7 |
| 11 |
|
Mazatlán FC | 5 | 2 | 0 | 3 | 5:7 | -2 | 6 |
| 12 |
|
CF Monterrey | 5 | 1 | 3 | 1 | 4:6 | -2 | 6 |
| 13 |
|
Atlas Guadalajara | 5 | 1 | 1 | 3 | 5:9 | -4 | 4 |
| 14 |
|
Santos Laguna | 5 | 1 | 1 | 3 | 4:10 | -6 | 4 |
| 15 |
|
FC Juárez | 5 | 1 | 1 | 3 | 5:12 | -7 | 4 |
| 16 |
|
Puebla FC | 5 | 1 | 0 | 4 | 5:13 | -8 | 3 |
| 17 |
|
Cruz Azul | 5 | 0 | 2 | 3 | 3:6 | -3 | 2 |
| 18 |
|
Gallos Blancos | 5 | 0 | 2 | 3 | 1:5 | -4 | 2 |
| Play-off |
