 |
 |
|
|
| 24.02.2022 | 16:00 | Gallos Blancos | - | Deportivo Toluca | 0:1 (0:1) | |
| 19:00 | CF Pachuca | - | Mazatlán FC | 3:2 (2:1) | ||
| 25.02.2022 | 16:00 | Club Necaxa | - | Club León | 0:3 (0:1) | |
| 17:00 | FC Juárez | - | UANL Tigres | 0:4 (0:2) | ||
| 26.02.2022 | 00:45 | Club Tijuana | - | Atlas Guadalajara | 2:1 (1:0) | |
| 16:00 | CF Monterrey | - | Atlético San Luis | 1:3 (0:2) | ||
| 16:00 | Pumas UNAM | - | CF América | 0:1 (0:0) | ||
| 16:00 | Deportivo Guadalajara | - | Puebla FC | 2:0 (1:0) | ||
| 27.02.2022 | 16:00 | Cruz Azul | - | Santos Laguna | 2:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético San Luis | 7 | 5 | 1 | 1 | 19:7 | 12 | 16 |
| 2 |
|
UANL Tigres | 7 | 5 | 1 | 1 | 17:7 | 10 | 16 |
| 3 |
|
Club León | 7 | 5 | 1 | 1 | 16:8 | 8 | 16 |
| 4 |
|
Club Tijuana | 7 | 5 | 1 | 1 | 11:5 | 6 | 16 |
| 5 |
|
CF Pachuca | 7 | 5 | 0 | 2 | 15:11 | 4 | 15 |
| 6 |
|
Deportivo Guadalajara | 7 | 4 | 1 | 2 | 7:6 | 1 | 13 |
| 7 |
|
Pumas UNAM | 7 | 3 | 3 | 1 | 7:5 | 2 | 12 |
| 8 |
|
Deportivo Toluca | 7 | 3 | 2 | 2 | 11:9 | 2 | 11 |
| 9 |
|
CF América | 7 | 3 | 1 | 3 | 11:7 | 4 | 10 |
| 10 |
|
Club Necaxa | 7 | 2 | 1 | 4 | 9:11 | -2 | 7 |
| 11 |
|
Mazatlán FC | 7 | 2 | 1 | 4 | 7:10 | -3 | 7 |
| 12 |
|
Santos Laguna | 7 | 2 | 1 | 4 | 7:13 | -6 | 7 |
| 13 |
|
Cruz Azul | 7 | 1 | 3 | 3 | 6:8 | -2 | 6 |
| 14 |
|
Puebla FC | 7 | 2 | 0 | 5 | 8:15 | -7 | 6 |
| 15 |
|
CF Monterrey | 7 | 1 | 3 | 3 | 5:12 | -7 | 6 |
| 16 |
|
Atlas Guadalajara | 7 | 1 | 2 | 4 | 6:11 | -5 | 5 |
| 17 |
|
FC Juárez | 7 | 1 | 1 | 5 | 6:18 | -12 | 4 |
| 18 |
|
Gallos Blancos | 7 | 0 | 3 | 4 | 1:6 | -5 | 3 |
| Play-off |
