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| 28.11.2005 | 20:00 | SBV Excelsior | - | Helmond Sport | 3:0 (3:0) | |
| 20:00 | FC Den Bosch | - | FC Omniworld | 1:1 (0:0) | ||
| 20:00 | FC Dordrecht | - | HFC Haarlem | 2:2 (1:1) | ||
| 20:00 | BV Veendam | - | FC Zwolle | 2:2 (0:1) | ||
| 20:00 | FC Volendam | - | MVV | 0:0 (0:0) | ||
| 20:00 | Stormvogels Telstar | - | SC Cambuur | 1:0 (0:0) | ||
| 20:00 | VVV-Venlo | - | Fortuna Sittard | 1:1 (1:1) | ||
| 29.11.2005 | 20:00 | FC Eindhoven | - | TOP Oss | 1:2 (0:0) | |
| 06.12.2005 | 20:00 | Go Ahead Eagles | - | FC Emmen | 1:4 (1:2) | |
| 12.12.2005 | 20:00 | AGOVV | - | De Graafschap | 2:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 20 | 13 | 3 | 4 | 38:12 | 26 | 42 |
| 2 |
|
VVV-Venlo | 20 | 12 | 5 | 3 | 31:11 | 20 | 41 |
| 3 |
|
FC Emmen | 20 | 12 | 2 | 6 | 42:24 | 18 | 38 |
| 4 |
|
FC Volendam | 20 | 11 | 5 | 4 | 33:18 | 15 | 38 |
| 5 |
|
FC Den Bosch | 20 | 10 | 6 | 4 | 36:25 | 11 | 36 |
| 6 |
|
FC Zwolle | 20 | 10 | 5 | 5 | 38:25 | 13 | 35 |
| 7 |
|
Helmond Sport | 20 | 10 | 3 | 7 | 30:32 | -2 | 33 |
| 8 |
|
De Graafschap | 20 | 8 | 5 | 7 | 29:26 | 3 | 29 |
| 9 |
|
MVV | 20 | 7 | 7 | 6 | 28:25 | 3 | 28 |
| 10 |
|
TOP Oss | 20 | 7 | 6 | 7 | 25:31 | -6 | 27 |
| 11 |
|
FC Dordrecht | 20 | 6 | 8 | 6 | 25:23 | 2 | 26 |
| 12 |
|
BV Veendam | 20 | 7 | 5 | 8 | 26:26 | 0 | 26 |
| 13 |
|
AGOVV | 20 | 7 | 3 | 10 | 36:35 | 1 | 24 |
| 14 |
|
Go Ahead Eagles | 20 | 6 | 6 | 8 | 25:32 | -7 | 24 |
| 15 |
|
Stormvogels Telstar | 20 | 5 | 7 | 8 | 18:28 | -10 | 22 |
| 16 |
|
HFC Haarlem | 20 | 6 | 4 | 10 | 22:40 | -18 | 22 |
| 17 |
|
FC Eindhoven | 20 | 5 | 4 | 11 | 28:33 | -5 | 19 |
| 18 |
|
SC Cambuur | 20 | 3 | 8 | 9 | 18:28 | -10 | 14 |
| 19 |
|
FC Omniworld | 20 | 3 | 4 | 13 | 23:49 | -26 | 13 |
| 20 |
|
Fortuna Sittard | 20 | 1 | 6 | 13 | 18:46 | -28 | 9 |
| Promotion |
