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| 02.12.2005 | 20:00 | MVV | - | FC Dordrecht | 2:1 (2:0) | |
| 20:00 | Helmond Sport | - | Go Ahead Eagles | 3:1 (1:0) | ||
| 20:00 | De Graafschap | - | FC Volendam | 3:1 (1:1) | ||
| 20:00 | Fortuna Sittard | - | AGOVV | 2:3 (1:2) | ||
| 20:00 | FC Zwolle | - | FC Eindhoven | 2:1 (1:0) | ||
| 20:00 | HFC Haarlem | - | BV Veendam | 4:1 (1:1) | ||
| 20:00 | FC Omniworld | - | SBV Excelsior | 1:1 (0:1) | ||
| 20:00 | FC Emmen | - | Stormvogels Telstar | 2:0 (0:0) | ||
| 20:00 | SC Cambuur | - | VVV-Venlo | 1:1 (1:1) | ||
| 04.12.2005 | 14:30 | TOP Oss | - | FC Den Bosch | 3:3 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 21 | 13 | 4 | 4 | 39:13 | 26 | 43 |
| 2 |
|
VVV-Venlo | 21 | 12 | 6 | 3 | 32:12 | 20 | 42 |
| 3 |
|
FC Emmen | 21 | 13 | 2 | 6 | 44:24 | 20 | 41 |
| 4 |
|
FC Zwolle | 21 | 11 | 5 | 5 | 40:26 | 14 | 38 |
| 5 |
|
FC Volendam | 21 | 11 | 5 | 5 | 34:21 | 13 | 38 |
| 6 |
|
FC Den Bosch | 21 | 10 | 7 | 4 | 39:28 | 11 | 37 |
| 7 |
|
Helmond Sport | 21 | 11 | 3 | 7 | 33:33 | 0 | 36 |
| 8 |
|
De Graafschap | 21 | 9 | 5 | 7 | 32:27 | 5 | 32 |
| 9 |
|
MVV | 21 | 8 | 7 | 6 | 30:26 | 4 | 31 |
| 10 |
|
TOP Oss | 21 | 7 | 7 | 7 | 28:34 | -6 | 28 |
| 11 |
|
AGOVV | 21 | 8 | 3 | 10 | 39:37 | 2 | 27 |
| 12 |
|
FC Dordrecht | 21 | 6 | 8 | 7 | 26:25 | 1 | 26 |
| 13 |
|
BV Veendam | 21 | 7 | 5 | 9 | 27:30 | -3 | 26 |
| 14 |
|
HFC Haarlem | 21 | 7 | 4 | 10 | 26:41 | -15 | 25 |
| 15 |
|
Go Ahead Eagles | 21 | 6 | 6 | 9 | 26:35 | -9 | 24 |
| 16 |
|
Stormvogels Telstar | 21 | 5 | 7 | 9 | 18:30 | -12 | 22 |
| 17 |
|
FC Eindhoven | 21 | 5 | 4 | 12 | 29:35 | -6 | 19 |
| 18 |
|
SC Cambuur | 21 | 3 | 9 | 9 | 19:29 | -10 | 15 |
| 19 |
|
FC Omniworld | 21 | 3 | 5 | 13 | 24:50 | -26 | 14 |
| 20 |
|
Fortuna Sittard | 21 | 1 | 6 | 14 | 20:49 | -29 | 9 |
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