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| H (Match allé) | Spartak Trnava | - | FK Senica | 3:0 (1:0) | ||
| R (match retour) | FK Senica | - | Spartak Trnava | 0:4 (0:2) | ||
| H (Match allé): 06.04.2022 19:45 | R (match retour): 20.04.2022 19:30 | vainqueur: Spartak Trnava | ||||
| H (Match allé) | AS Trenčín | - | Slovan Bratislava | 0:0 (0:0) | ||
| R (match retour) | Slovan Bratislava | - | AS Trenčín | 2:1 (2:0) | ||
| H (Match allé): 07.04.2022 19:45 | R (match retour): 19.04.2022 19:30 | vainqueur: Slovan Bratislava | ||||
