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| 07.05.2022 | 14:00 | Ankaraspor | - | 1461 Trabzon FK | 0:0 (0:0) | |
| 14:00 | Bayburt İl Özel İdare | - | Ergene Velimeşe | 1:0 (1:0) | ||
| 14:00 | Bodrumspor | - | Adıyamanspor | 1:2 (0:1) | ||
| 14:00 | Çorum FK | - | Afjet Afyonspor | 3:2 (1:0) | ||
| 14:00 | Kahramanmaraşspor | - | Turgutluspor | 0:1 (0:0) | ||
| 14:00 | Sarıyer SK | - | Diyarbekirspor | 3:1 (3:0) | ||
| 14:00 | Serik Belediyespor | - | Etimesgut Belediyespor | 1:0 (1:0) | ||
| 14:00 | Sivas Belediyespor | - | Sakaryaspor | 1:0 (1:0) | ||
| 14:00 | Somaspor | - | Inegölspor | 0:0 (0:0) | ||
| 14:00 | Vanspor FK | - | Niğde Anadolu FK | 4:2 (3:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 38 | 25 | 9 | 4 | 75:24 | 51 | 84 |
| 2 |
|
1461 Trabzon FK | 38 | 22 | 8 | 8 | 63:32 | 31 | 74 |
| 3 |
|
Bodrumspor | 38 | 21 | 9 | 8 | 61:27 | 34 | 72 |
| 4 |
|
Sivas Belediyespor | 38 | 20 | 9 | 9 | 66:34 | 32 | 69 |
| 5 |
|
Bayburt İl Özel İdare | 38 | 19 | 9 | 10 | 50:35 | 15 | 66 |
| 6 |
|
Vanspor FK | 38 | 18 | 12 | 8 | 55:46 | 9 | 66 |
| 7 |
|
Çorum FK | 38 | 18 | 11 | 9 | 58:41 | 17 | 65 |
| 8 |
|
Afjet Afyonspor | 38 | 18 | 8 | 12 | 67:44 | 23 | 62 |
| 9 |
|
Ankaraspor | 38 | 14 | 13 | 11 | 53:40 | 13 | 55 |
| 10 |
|
Somaspor | 38 | 15 | 8 | 15 | 50:50 | 0 | 53 |
| 11 |
|
Inegölspor | 38 | 14 | 9 | 15 | 51:54 | -3 | 51 |
| 12 |
|
Etimesgut Belediyespor | 38 | 12 | 11 | 15 | 45:54 | -9 | 47 |
| 13 |
|
Serik Belediyespor | 38 | 13 | 6 | 19 | 47:55 | -8 | 45 |
| 14 |
|
Sarıyer SK | 38 | 11 | 10 | 17 | 50:59 | -9 | 43 |
| 15 |
|
Diyarbekirspor | 38 | 12 | 5 | 21 | 34:46 | -12 | 41 |
| 16 |
|
Adıyamanspor | 38 | 12 | 5 | 21 | 47:71 | -24 | 41 |
| 17 |
|
Turgutluspor | 38 | 9 | 10 | 19 | 31:62 | -31 | 37 |
| 18 |
|
Ergene Velimeşe | 38 | 10 | 5 | 23 | 38:72 | -34 | 35 |
| 19 |
|
Niğde Anadolu FK | 38 | 7 | 8 | 23 | 45:84 | -39 | 29 |
| 20 |
|
Kahramanmaraşspor | 38 | 4 | 7 | 27 | 23:79 | -56 | 19 |
| Promotion | |
| Play-off | |
| Relégation |
