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| H (Match allé) | Real Salt Lake | - | Seattle Sounders | 3:0 (1:0) | ||
| R (match retour) | Seattle Sounders | - | Real Salt Lake | 2:0 (0:0) | ||
| H (Match allé): 30.10.2011 03:00 | R (match retour): 03.11.2011 03:00 | vainqueur: Real Salt Lake | ||||
| H (Match allé) | New York RB | - | Los Angeles Galaxy | 0:1 (0:1) | ||
| R (match retour) | Los Angeles Galaxy | - | New York RB | 2:1 (1:1) | ||
| H (Match allé): 30.10.2011 20:00 | R (match retour): 04.11.2011 04:00 | vainqueur: Los Angeles Galaxy | ||||
| H (Match allé) | Philadelphia Union | - | Houston Dynamo | 1:2 (1:2) | ||
| R (match retour) | Houston Dynamo | - | Philadelphia Union | 1:0 (1:0) | ||
| H (Match allé): 30.10.2011 22:00 | R (match retour): 04.11.2011 01:30 | vainqueur: Houston Dynamo | ||||
| H (Match allé) | Colorado Rapids | - | Sporting Kansas City | 0:2 (0:0) | ||
| R (match retour) | Sporting Kansas City | - | Colorado Rapids | 2:0 (1:0) | ||
| H (Match allé): 31.10.2011 00:30 | R (match retour): 03.11.2011 01:00 | vainqueur: Sporting Kansas City | ||||
