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| H (Match allé) | Columbus Crew | - | New York RB | 2:0 (1:0) | ||
| R (match retour) | New York RB | - | Columbus Crew | 1:0 (0:0) | ||
| H (Match allé): 22.11.2015 23:00 | R (match retour): 30.11.2015 01:30 | vainqueur: Columbus Crew | ||||
| H (Match allé) | Portland Timbers | - | FC Dallas | 3:1 (1:0) | ||
| R (match retour) | FC Dallas | - | Portland Timbers | 2:2 (0:0) | ||
| H (Match allé): 23.11.2015 01:30 | R (match retour): 29.11.2015 23:00 | vainqueur: Portland Timbers | ||||
