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| H (Match allé) | Libertad | - | Palmeiras | 1:1 (0:1) | ||
| R (match retour) | Palmeiras | - | Libertad | 3:0 (1:0) | ||
| H (Match allé): 09.12.2020 01:30 | R (match retour): 16.12.2020 01:30 | vainqueur: Palmeiras | ||||
| H (Match allé) | Grêmio Porto Alegre | - | Santos FC | 1:1 (0:1) | ||
| R (match retour) | Santos FC | - | Grêmio Porto Alegre | 4:1 (2:0) | ||
| H (Match allé): 09.12.2020 23:15 | R (match retour): 16.12.2020 23:15 | vainqueur: Santos FC | ||||
| H (Match allé) | River Plate | - | Nacional | 2:0 (0:0) | ||
| R (match retour) | Nacional | - | River Plate | 2:6 (1:2) | ||
| H (Match allé): 11.12.2020 01:30 | R (match retour): 18.12.2020 01:30 | vainqueur: River Plate | ||||
| H (Match allé) | Racing Club | - | Boca Juniors | 1:0 (0:0) | ||
| R (match retour) | Boca Juniors | - | Racing Club | 2:0 (1:0) | ||
| H (Match allé): 17.12.2020 01:30 | R (match retour): 24.12.2020 01:30 | vainqueur: Boca Juniors | ||||
