 |
 |
|
|
| 23.04.2021 | 16:00 | Puebla FC | - | Pumas UNAM | 3:2 (2:1) | |
| 17:00 | Mazatlán FC | - | Club León | 1:3 (1:0) | ||
| 24.04.2021 | 00:45 | Club Tijuana | - | Club Necaxa | 3:1 (2:0) | |
| 16:00 | Atlas Guadalajara | - | Deportivo Guadalajara | 3:2 (0:1) | ||
| 16:00 | UANL Tigres | - | CF Monterrey | 2:2 (0:1) | ||
| 18:45 | Cruz Azul | - | Atlético San Luis | 0:1 (0:0) | ||
| 25.04.2021 | 16:00 | Deportivo Toluca | - | CF América | 0:2 (0:0) | |
| 16:00 | Gallos Blancos | - | FC Juárez | 0:2 (0:1) | ||
| 26.04.2021 | 19:00 | CF Pachuca | - | Santos Laguna | 3:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 16 | 10 | 4 | 2 | 37:20 | 17 | 34 |
| 2 |
|
CF Monterrey | 16 | 10 | 2 | 4 | 28:18 | 10 | 32 |
| 3 |
|
CF América | 16 | 9 | 3 | 4 | 28:13 | 15 | 30 |
| 4 |
|
Club Tijuana | 16 | 9 | 1 | 6 | 25:16 | 9 | 28 |
| 5 |
|
Deportivo Toluca | 16 | 8 | 3 | 5 | 29:20 | 9 | 27 |
| 6 |
|
Atlas Guadalajara | 16 | 8 | 3 | 5 | 23:17 | 6 | 27 |
| 7 |
|
FC Juárez | 16 | 7 | 4 | 5 | 19:19 | 0 | 25 |
| 8 |
|
Club León | 16 | 7 | 2 | 7 | 23:29 | -6 | 23 |
| 9 |
|
UANL Tigres | 16 | 6 | 4 | 6 | 26:19 | 7 | 22 |
| 10 |
|
Mazatlán FC | 16 | 6 | 4 | 6 | 26:28 | -2 | 22 |
| 11 |
|
Puebla FC | 16 | 7 | 0 | 9 | 32:40 | -8 | 21 |
| 12 |
|
Santos Laguna | 16 | 5 | 5 | 6 | 25:21 | 4 | 20 |
| 13 |
|
Deportivo Guadalajara | 16 | 6 | 1 | 9 | 27:28 | -1 | 19 |
| 14 |
|
Atlético San Luis | 16 | 6 | 1 | 9 | 23:34 | -11 | 19 |
| 15 |
|
Pumas UNAM | 16 | 4 | 4 | 8 | 24:33 | -9 | 16 |
| 16 |
|
Club Necaxa | 16 | 4 | 3 | 9 | 17:24 | -7 | 15 |
| 17 |
|
Cruz Azul | 16 | 4 | 3 | 9 | 11:26 | -15 | 15 |
| 18 |
|
Gallos Blancos | 16 | 4 | 1 | 11 | 13:31 | -18 | 13 |
| Play-off |
