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| 18.09.2021 | 16:00 | SC Velbert | - | FSV Duisburg | 2:0 (0:0) | |
| 19.09.2021 | 15:00 | TV Jahn Hiesfeld | - | 1. FC Monheim | 0:2 (0:0) | |
| 15:00 | Cronenberger SC | - | TuRU Düsseldorf | 0:3 (0:1) | ||
| 15:00 | SpVg Schonnebeck | - | Germania Ratingen 04/19 | 0:2 (0:1) | ||
| 15:00 | TSV Meerbusch | - | TVD Velbert | 2:1 (0:0) | ||
| 15:00 | 1. FC Kleve | - | SpVgg Sterkrade-Nord | 2:1 (2:1) | ||
| 15:00 | Sportfreunde Niederwenigern | - | 1. FC Mönchengladbach | 2:1 (0:0) | ||
| 15:15 | SC Union Nettetal | - | DJK Teutonia St. Tönis | 0:1 (0:0) | ||
| 15:30 | SC Düsseldorf-West | - | FC Kray | 1:0 (1:0) | ||
| 15:30 | 1. FC Bocholt | - | SSVg Velbert | 1:1 (1:0) | ||
| 27.10.2021 | 19:30 | Sportfreunde Baumberg | - | Schwarz-Weiß Essen | 3:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
TVD Velbert | 5 | 4 | 0 | 1 | 7:4 | 3 | 12 |
| 2 |
|
SSVg Velbert | 5 | 3 | 2 | 0 | 12:5 | 7 | 11 |
| 3 |
|
SpVg Schonnebeck | 5 | 3 | 1 | 1 | 16:7 | 9 | 10 |
| 4 |
|
SC Velbert | 5 | 3 | 1 | 1 | 11:4 | 7 | 10 |
| 5 |
|
Germania Ratingen 04/19 | 5 | 3 | 1 | 1 | 8:2 | 6 | 10 |
| 6 |
|
VfB 03 Hilden | 4 | 3 | 0 | 1 | 7:4 | 3 | 9 |
| 7 |
|
Schwarz-Weiß Essen | 5 | 3 | 0 | 2 | 10:11 | -1 | 9 |
| 8 |
|
1. FC Bocholt | 4 | 2 | 2 | 0 | 13:4 | 9 | 8 |
| 9 |
|
DJK Teutonia St. Tönis | 5 | 2 | 2 | 1 | 9:8 | 1 | 8 |
| 10 |
|
1. FC Kleve | 5 | 2 | 2 | 1 | 6:5 | 1 | 8 |
| 11 |
|
Sportfreunde Niederwenigern | 5 | 2 | 2 | 1 | 9:10 | -1 | 8 |
| 12 |
|
TuRU Düsseldorf | 5 | 2 | 2 | 1 | 11:10 | 1 | 8 |
| 13 |
|
FC Kray | 5 | 2 | 1 | 2 | 11:11 | 0 | 7 |
| 14 |
|
1. FC Monheim | 5 | 2 | 1 | 2 | 5:5 | 0 | 7 |
| 15 |
|
Sportfreunde Baumberg | 5 | 2 | 0 | 3 | 10:11 | -1 | 6 |
| 16 |
|
Cronenberger SC | 5 | 1 | 2 | 2 | 5:7 | -2 | 5 |
| 17 |
|
SC Düsseldorf-West | 5 | 1 | 1 | 3 | 6:12 | -6 | 4 |
| 18 |
|
FSV Duisburg | 4 | 1 | 0 | 3 | 5:7 | -2 | 3 |
| 19 |
|
SC Union Nettetal | 5 | 1 | 0 | 4 | 6:10 | -4 | 3 |
| 20 |
|
1. FC Mönchengladbach | 4 | 1 | 0 | 3 | 6:12 | -6 | 3 |
| 21 |
|
TSV Meerbusch | 4 | 1 | 0 | 3 | 5:12 | -7 | 3 |
| 22 |
|
SpVgg Sterkrade-Nord | 5 | 0 | 1 | 4 | 5:13 | -8 | 1 |
| 23 |
|
TV Jahn Hiesfeld | 5 | 0 | 1 | 4 | 3:12 | -9 | 1 |
| Play-off | |
| Play-off |
