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| 06.06.2021 | 16:00 | Olympia Agnonese | - | Atletico Terme Fiuggi | 0:2 | |
| 16:00 | Campobasso | - | Porto Sant'Elpidio | 1:1 | ||
| 16:00 | GSD Castelfidardo | - | Real Giulianova | 0:0 | ||
| 16:00 | Castelnuovo Vomano | - | Tolentino | 1:2 | ||
| 16:00 | FC Aprilia | - | ASD Pineto Calcio | 0:1 | ||
| 16:00 | Matese | - | US Recanatese | 3:2 | ||
| 16:00 | Montegiorgio Calcio | - | FC Rieti | 2:0 | ||
| 16:00 | SN Notaresco | - | Vastogirardi | 3:0 | ||
| 16:00 | Vastese Calcio | - | CynthiAlbalonga | 3:1 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Campobasso | 31 | 20 | 8 | 3 | 58:24 | 34 | 68 |
| 2 |
|
SN Notaresco | 31 | 18 | 8 | 5 | 53:26 | 27 | 62 |
| 3 |
|
ASD Pineto Calcio | 31 | 14 | 10 | 7 | 40:28 | 12 | 52 |
| 4 |
|
Matese | 31 | 14 | 9 | 8 | 41:34 | 7 | 51 |
| 5 |
|
CynthiAlbalonga | 31 | 12 | 13 | 6 | 44:33 | 11 | 49 |
| 6 |
|
GSD Castelfidardo | 31 | 11 | 13 | 7 | 36:32 | 4 | 46 |
| 7 |
|
Castelnuovo Vomano | 31 | 13 | 7 | 11 | 49:49 | 0 | 46 |
| 8 |
|
US Recanatese | 31 | 12 | 9 | 10 | 55:39 | 16 | 45 |
| 9 |
|
Montegiorgio Calcio | 31 | 13 | 6 | 12 | 39:37 | 2 | 45 |
| 10 |
|
FC Rieti | 31 | 12 | 7 | 12 | 36:38 | -2 | 43 |
| 11 |
|
Vastese Calcio | 31 | 10 | 13 | 8 | 42:36 | 6 | 42 |
| 12 |
|
Vastogirardi | 31 | 10 | 9 | 12 | 42:43 | -1 | 39 |
| 13 |
|
FC Aprilia | 31 | 9 | 11 | 11 | 37:44 | -7 | 38 |
| 14 |
|
Atletico Terme Fiuggi | 31 | 7 | 15 | 9 | 37:36 | 1 | 36 |
| 15 |
|
Tolentino | 31 | 8 | 12 | 11 | 48:48 | 0 | 36 |
| 16 |
|
Real Giulianova | 31 | 7 | 8 | 16 | 28:44 | -16 | 29 |
| 17 |
|
Olympia Agnonese | 31 | 3 | 5 | 23 | 21:72 | -51 | 14 |
| 18 |
|
Porto Sant'Elpidio | 31 | 2 | 5 | 24 | 17:60 | -43 | 11 |
| Promotion | |
| Play-off | |
| Relégation |
