Atletico Madrid boss Diego Simeone sprung a huge surprise by handing midfielder Cani his full debut as the Spaniards look to overturn a 1-0 first leg deficit against Bayer Leverkusen in their Champions League last 16 tie on Tuesday.

The 33-year-old has made just four substitute appearances for Atletico since joining on loan from Villarreal in January.

Cani takes Atletico captain Gabi's place with Spanish international Koke moving into central midfield.

The suspended Diego Godin and Tiago are replaced by Jose Maria Gimenez and Mario Suarez respectively, whilst Mario Mandzukic is preferred in attack to Fernando Torres.

Leverkusen coach Roger Schmidt makes just one change from the first leg with Turkish defender Omer Toprak replacing Kyriakos Papadopoulos.

Starting line-ups:

Atletico Madrid (ESP) (4-4-2)

Miguel Angel Moya; Juanfran; Jose Maria Gimenez, Miranda, Jesus Gamez; Cani, Koke (capt), Mario Suarez, Arda Turan; Antoine Griezmann, Mario Mandzukic

Coach: Diego Simeone (ARG)

Bayer Leverkusen (GER) (4-2-3-1)

Bernd Leno; Roberto Hilbert, Emir Spahic, Omer Toprak, Wendell; Sven Bender (capt), Gonzalo Castro; Karim Bellarabi, Hakan Calhanoglu, Son Hueng-Min; Josip Drmic

Coach: Roger Schmidt (GER)

Referee: Nicola Rizzoli (ITA)